Endocrine Abstracts

The spectrum of symptoms associated with hypoparathyroidism span from virtually none to severely debilitating fatigue, memory loss, muscle cramps, and paresthesia. Until recently disease management has focused on securing stable serum calcium values at the lower end of the reference range using potent active vitamin D analogues like Etalpha and Rocaltrol, together with calcium supplementation. Recently maintenance of adequate levels of 25(OH)D have also been mentioned as being...

Background: Secondary hyperparathyroidism (SHPT) is common in obesity, and a concern after obesity surgery due to negative impact on bone. Longitudinal data is sparse, and relationships with vitamin D and calcium levels are unclear. We studied the prevalence of SHPT over five years after Roux-en-Y gastric bypass (RYGB) and investigated whether SHPT was associated with serum levels of 25-hydroxyvitamin D (25(OH)D) and ionized calcium (iCa).Methods: 347 of...

Background and methods: The HORIZON-PFT is a multinational, 3-year, randomized, double-blind, placebo-controlled trial evaluating the potential of once-yearly zoledronic acid (ZOL) 5 mg, infused over 15 minutes, to decrease risk of fracture in 7736 postmenopausal osteoporotic women 65–89 years of age.Results: Treatment with ZOL 5 mg resulted in significant relative risk reductions in morphometric vertebral fracture of 70% vs PBO (3.8% vs 12.8%; 95% ...

Objectives and methods: The HORIZON-PFT is a multinational, 3-year, randomized, double-blind, placebo-controlled trial evaluating the potential of once-yearly zoledronic acid (ZOL) 5 mg, infused over 15 minutes, to decrease risk of fracture in 7736 postmenopausal osteoporotic women 65–89 years of age.Results: Treatment with ZOL 5 mg resulted in significant relative risk reductions in morphometric vertebral fracture of 70% vs PBO (3.8% vs 12.8%; 95% ...